![]() NPCs do not generate the non-neural cells that are also present in the CNS, such as immune system cells. “Neural progenitor cells (NPCs)” are the progenitor cells of the CNS that give rise to many, if not all, of the glial and neuronal cell types that populate the CNS. Many types of multipotent stem cells exist and can also be referred to as “progenitor cells.” The embryonic layers and each specific tissue, such as the central nervous system (CNS) tissue, develop from cellular divisions of progenitor cells. The embryonic stem cells that are present in the inner cell mass of the blastocyst are an example of pluripotent stem cells. Stem cells can be “pluripotent precursor cells” that give rise to all cell types within an organism, or “multipotent precursor cells” that have the capacity to differentiate into a subset of cell types. “Stem cells” have the capacity to undergo self-renewing divisions that produce additional stem cells with the same properties and potential, and divisions that produce daughter cells that differentiate into multiple cell types. Here we review past and current terminology used to refer to NPCs, including embryonic and adult precursor cells of the cerebral cortex and hippocampus. While there is a trend toward consensus and streamlining of terminology over time, to this day scientists use different terms for NPCs that reflect their field and perspective, i.e., terms arising from molecular, cellular, or anatomical sciences. As the field gained knowledge through a combination of technical advance and individual insight, the terminology describing NPCs changed to incorporate new information. Since descriptions of neural precursor cells (NPCs) were published in the late 19th century, neuroanatomists have used a variety of terms to describe these cells, each term reflecting contemporary understanding of cellular characteristics and function. 3Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, Sacramento, CA, United States. ![]() 2UC Davis Medical Center, MIND Institute, Sacramento, CA, United States.1Department of Pathology and Laboratory Medicine, Institute for Pediatric Regenerative Medicine and Shriners Hospitals for Children of Northern California, UC Davis School of Medicine, Sacramento, CA, United States.Verónica Martínez-Cerdeño 1,2* and Stephen C.
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